High intensity sequencing of plasma cfDNA and WBC gDNA
We sought to define the technical feasibility of a high-intensity sequencing assay of cfDNA and matched white-blood cell (WBC) DNA covering a large genomic region (508 genes, 2Mb, 60,000x raw-depth) in a prospective study of 124 metastatic cancer patients, with contemporaneous matched metastatic tumor tissue biopsies, and age-matched 47 non-cancer controls.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
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High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.
Nat Med 25: 2019 1928-1937
Combining variant detection and fragment length analysis improves detection of minimal residual disease in postsurgery circulating tumour DNA of stage II-IIIA NSCLC patients.
Mol Oncol 16: 2022 2719-2732