High intensity sequencing of plasma cfDNA and WBC gDNA
We sought to define the technical feasibility of a high-intensity sequencing assay of cfDNA and matched white-blood cell (WBC) DNA covering a large genomic region (508 genes, 2Mb, 60,000x raw-depth) in a prospective study of 124 metastatic cancer patients, with contemporaneous matched metastatic tumor tissue biopsies, and age-matched 47 non-cancer controls.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
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EGAD00001005302 | 396 |
Publications | Citations |
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High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.
Nat Med 25: 2019 1928-1937 |
313 |
Combining variant detection and fragment length analysis improves detection of minimal residual disease in postsurgery circulating tumour DNA of stage II-IIIA NSCLC patients.
Mol Oncol 16: 2022 2719-2732 |
11 |
Fragmentomic analysis of circulating tumor DNA-targeted cancer panels.
Ann Oncol 34: 2023 813-825 |
4 |
Aging clock based on nucleosome reorganisation derived from cell-free DNA.
Aging Cell 23: 2024 e14100 |
3 |