The whole genome landscape of Burkitt lymphoma subtypes

Study ID Alternative Stable ID Type
EGAS00001003778 Other

Study Description

Burkitt lymphoma (BL) is an aggressive, MYC-driven lymphoma comprising three distinct clinical subtypes, including sporadic BLs that occur worldwide, endemic BLs that occur predominantly in sub-Saharan Africa, and immunodeficiency-associated BLs that occur primarily in the setting of HIV. In this study, we comprehensively delineated the genomic basis of BL through whole genome sequencing of 101 tumors representing all 3 subtypes of BL to identify 72 driver genes. These data were additionally informed by CRISPR screens in BL cell lines to functionally annotate the role of oncogenic drivers. Nearly every driver gene was found to have both coding and non-coding mutations highlighting the importance of whole genome sequencing for identifying driver events. Our data implicate coding and non-coding mutations in IGLL5, BACH2, SIN3A and DNMT1. EBV infection was associated with higher mutation load, with EBV type 1 showing a higher mutational burdens than type 2 EBV. While sporadic and immunodeficiency-associated BLs had similar genetic profiles, endemic BLs manifested more frequent ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Whole genome sequencing data for 101 BL patients and transcriptome sequencing for 82 (out of 101) BL patients.
HiSeq X Ten,Illumina HiSeq 2500 183

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