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Comprehensive molecular profiling of high-grade serous ovarian cancer

The diversity and heterogeneity within high-grade serous ovarian cancer (HGSC) is not well understood. Here, we performed comprehensive molecular analysis, including high-pass whole genome sequencing, targeted deep sequencing, RNA sequencing, reverse phase protein arrays and immune assessment, on primary and metastatic sites from highly clinically annotated HGSC samples. Samples were obtained pre-treatment based on a laparoscopic triage algorithm from patients who underwent R0 tumor debulking, or received neoadjuvant chemotherapy (NACT) with excellent or poor response.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005238 Illumina HiSeq 2000 74
EGAD00001005239 Illumina HiSeq 2000 75
EGAD00001005240 HiSeq X Ten 103
Publications Citations
Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer.
Cell Rep 31: 2020 107502
Spatially resolved transcriptomics of high-grade serous ovarian carcinoma.
iScience 25: 2022 103923