Single cell sequencing: Capturing the origin and dynamics of chromosomal copy-number heterogeneity

Study ID Alternative Stable ID Type
EGAS00001003812 Other

Study Description

Shallow whole-genome sequencing of single cells from individual clonal (patient-derived colorectal cancer) organoids was performed to investigate the degree of copy-number heterogeneity that emerges and propagates during clonal organoid outgrowth of a single cancerous cell. Selected single cells were sequenced with higher coverage. In addition, daughter cells were isolated to directly link mitotic chromatin errors to chromosomal copy number changes.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Dataset contains 854 single cell sequenced colorectal cancer organoids.

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