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Lothian Birth Cohort 1921 whole genome sequencing study

297 members of the Lothian Birth Cohort 1921 (LBC1921) were sequenced using the Illumina HiSeq X platform. The LBC1921 are a relatively healthy cohort of 550 individuals who underwent cognitive and medical testing at a mean age of 79.1 (SD=0.6) years. They have since undergone four further waves of testing, approximately three years apart.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005477 Illumina HiSeq X Ten 296
EGAD00001006416 Illumina HiSeq X Ten 297
EGAD00001008775 Illumina HiSeq X Ten 297
Publications Citations
Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions.
PLoS Genet 15: 2019 e1008480
Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation.
Nat Commun 11: 2020 343