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Lothian Birth Cohort 1936 whole genome sequencing study

1075 members of the Lothian Birth Cohort 1936 (LBC1936) were sequenced using the Illumina HiSeq X platform. The LBC1936 are a relatively healthy cohort of 1091 individuals who underwent cognitive and medical testing at a mean age of 69.5 (SD=0.8) years. They have since undergone four further waves of testing, approximately three years apart.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005478 Illumina HiSeq X Ten 1068
EGAD00001006414 Illumina HiSeq X Ten 1075
EGAD00001008774 Illumina HiSeq X Ten 1075
Publications Citations
Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions.
PLoS Genet 15: 2019 e1008480
12
Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation.
Nat Commun 11: 2020 343
5
Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936.
Stem Cell Res 46: 2020 101851
6
Rare genetic variants underlie outlying levels of DNA methylation and gene-expression.
Hum Mol Genet 32: 2023 1912-1921
1