Study

Gene epression regulation in cytokine induced immune cell states

Study ID Alternative Stable ID Type
EGAS00001003823 Gene Regulation Study

Study Description

We isolated T cells and monocotyes from healthy platelet donors and cultured them in resting and stimulated conditions with addition of a range of cytokines. We performed RNA sequencing to assess impact of different disease-relevant cytokines upon immune cell responses.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001005291
Cytokines affect T cell responses by polarising them to different phenotypes. We isolated T cells from healthy platelet donors and cultured them in resting and stimulated conditions, as well as in the presence of Th1, Th2, Th17 and iTreg cocktail. In addition, T cells were stimulated in the presence of IL-10, IL-21, IL-27, IFNb and TNFa. We performed bulk RNA sequencing to assess impact of different disease-relevant cytokines upon T cell response.
Illumina HiSeq 2500 141

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