Study

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

Study ID Alternative Stable ID Type
EGAS00001003852 Other

Study Description

We performed scRNA-seq of patient-derived glioblastoma cells alone or after co-culture with human iPSC-derived cerebral organoid cells. Transcriptional changes implicated in the invasion process that are coherent across patient samples indicate that GBM cells reactively upregulate genes required for their dispersion. Potential interactions between GBM and organoid cells identified by an in silico receptor-ligand pairing screen suggest functional therapeutic targets.

Study Datasets 1 dataset.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005315
NA
NextSeq 500 9

Who archives the data?

Publications

Citations

Retrieving...
Retrieving...