Evolution of the cancer epigenome in myeloproliferative neoplasms TGS

Study ID Alternative Stable ID Type
EGAS00001003863 Cancer Genomics

Study Description

Targeted sequencing of haematopoietic colonies.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Mutations in cancer-associated genes drive tumour outgrowth. However, the timing of driver mutations and dynamics of clonal expansion that lead to human cancers are largely unknown. We used 580,133 somatic mutations from whole-genome sequencing of 1013 clonal haematopoietic colonies to reconstruct the phylogeny of haematopoiesis, from embryogenesis to clinical disease, in 12 patients with myeloproliferative neoplasms which are blood cancers more common in older age. JAK2V617F, the pathognomonic ... (Show More)
Illumina NovaSeq 6000 57

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