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Bottleneck sequencing of human tissue including neurons, cord blood, sperm This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006459 HiSeq X Ten Illumina HiSeq 2500 Illumina HiSeq 4000 Illumina NovaSeq 6000 192
EGAD00001007958 Illumina NovaSeq 6000 210
EGAD00001007997 Illumina NovaSeq 6000 31
Publications Citations
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases.
Nat Genet 53: 2021 1434-1442
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
Nat Commun 13: 2022 3949