Genomic and epigenomic insights into the origin, pathogenesis and clinical behavior of mantle cell lymphoma subtypes

Study

Study ID	Alternative Stable ID	Type
EGAS00001004165		Other

Study Description

Mantle Cell Lymphoma can be subdivided into conventional (cMCL) and leukemic non-nodal MCL (nnMCL), which differ in the cell of origin, gene expression, biological characteristics and clinical evolution. Using genomic, epigenomic and transcriptomic data we identified common and particular alterations in the two subtypes, either point mutations, copy number alterations or structural variants some of them with prognostic impact.

Study Datasets 4 datasets.

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Dataset ID	Description	Technology	Samples
EGAD00001006025	We have performed a comprehensive and integrative genomic study of mantle cell lymphoma (MCL) to elucidate the features that may determine the different clinical and biological behavior of the two molecular subtypes of this lymphoma, conventional (cMCL) and leukemic non-nodal MCL (nnMCL). This data integrated with epigenomics and transcriptomics has allowed to uncover novel molecular mechanisms in the origin and development of these tumors and provide relevant information to stratify patients ... (Show More) We have performed a comprehensive and integrative genomic study of mantle cell lymphoma (MCL) to elucidate the features that may determine the different clinical and biological behavior of the two molecular subtypes of this lymphoma, conventional (cMCL) and leukemic non-nodal MCL (nnMCL). This data integrated with epigenomics and transcriptomics has allowed to uncover novel molecular mechanisms in the origin and development of these tumors and provide relevant information to stratify patients in different risk groups.	Illumina MiSeq	114
EGAD00010001841	Copy Number Alterations arrays from 153 samples performed by Affymetrix 6.0 and Oncoscan CNV platforms Copy Number Alterations arrays from 153 samples performed by Affymetrix 6.0 and Oncoscan CNV platforms	Affymetrix 6.0; Cytoscan	153
EGAD00010001842	Gene Expression Profiling from 44 Mantle Cell Lymphoma cases Gene Expression Profiling from 44 Mantle Cell Lymphoma cases	Human Genome U219 array plate	44
EGAD00010001877	DNA methylation profiling from 70 Mantle Cell Lymphoma cases DNA methylation profiling from 70 Mantle Cell Lymphoma cases	Infinium MethylationEPIC BeadChip	70

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