Genomic and epigenomic insights into the origin, pathogenesis and clinical behavior of mantle cell lymphoma subtypes

Study ID Alternative Stable ID Type
EGAS00001004165 Other

Study Description

Mantle Cell Lymphoma can be subdivided into conventional (cMCL) and leukemic non-nodal MCL (nnMCL), which differ in the cell of origin, gene expression, biological characteristics and clinical evolution. Using genomic, epigenomic and transcriptomic data we identified common and particular alterations in the two subtypes, either point mutations, copy number alterations or structural variants some of them with prognostic impact.

Study Datasets 4 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
We have performed a comprehensive and integrative genomic study of mantle cell lymphoma (MCL) to elucidate the features that may determine the different clinical and biological behavior of the two molecular subtypes of this lymphoma, conventional (cMCL) and leukemic non-nodal MCL (nnMCL). This data integrated with epigenomics and transcriptomics has allowed to uncover novel molecular mechanisms in the origin and development of these tumors and provide relevant information to stratify patients ... (Show More)
Illumina MiSeq 114
Copy Number Alterations arrays from 153 samples performed by Affymetrix 6.0 and Oncoscan CNV platforms
Affymetrix 6.0; Cytoscan 153
Gene Expression Profiling from 44 Mantle Cell Lymphoma cases
Human Genome U219 array plate 44
DNA methylation profiling from 70 Mantle Cell Lymphoma cases
Infinium MethylationEPIC BeadChip 70

Who archives the data?