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Genomic and epigenomic insights into the origin, pathogenesis and clinical behavior of mantle cell lymphoma subtypes

Mantle Cell Lymphoma can be subdivided into conventional (cMCL) and leukemic non-nodal MCL (nnMCL), which differ in the cell of origin, gene expression, biological characteristics and clinical evolution. Using genomic, epigenomic and transcriptomic data we identified common and particular alterations in the two subtypes, either point mutations, copy number alterations or structural variants some of them with prognostic impact.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006025 Illumina MiSeq 114
EGAD00010001841 Affymetrix 6.0; Cytoscan 153
EGAD00010001842 Human Genome U219 array plate 44
EGAD00010001877 Infinium MethylationEPIC BeadChip 70
Publications Citations
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes.
Blood 136: 2020 1419-1432
79
IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms.
Nat Commun 11: 2020 3390
21
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome.
Nat Cancer 1: 2020 1066-1081
30
PanCancer analysis of somatic mutations in repetitive regions reveals recurrent mutations in snRNA U2.
NPJ Genom Med 7: 2022 19
2
Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma.
Leukemia 37: 2023 408-421
1
SOX11/PRDX2 axis modulates redox homeostasis and chemoresistance in aggressive mantle cell lymphoma.
Sci Rep 14: 2024 7863
0