Longitudinal therapy monitoring of ALK-positive non-small cell lung cancer (copy number, cell-free DNA)

Study

Study ID	Alternative Stable ID	Type
EGAS00001004276		Other

Study Description

Clinical courses of non-small cell lung cancer patients with ALK rearrangements (ALK+ NSCLC) vary widely. We analyzed 271 longitudinal plasma samples from 73 patients with advanced ALK+ NSCLC treated with ALK tyrosine kinase inhibitors by combined hybrid-capture-based targeted sequencing (average 4,100x coverage) for mutation analysis and shallow whole genome sequencing (0.5x coverage) for global copy number profiling from cfDNA.

Study Datasets 3 datasets.

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Dataset ID	Description	Technology	Samples
EGAD00001006297	270 samples with ALK-positiv non-small cell lung cancer, targeted sequencing (198 kb panel size) 270 samples with ALK-positiv non-small cell lung cancer, targeted sequencing (198 kb panel size)		270
EGAD00001006298	268 samples with ALK-positiv non-small cell lung cancer, ultra-low coverage whole genome sequencing 268 samples with ALK-positiv non-small cell lung cancer, ultra-low coverage whole genome sequencing		268
EGAD00001007817	This dataset contains 538 Tumor and Control WGS and WES files for samples already submitted and published in study EGAS00001004276 This dataset contains 538 Tumor and Control WGS and WES files for samples already submitted and published in study EGAS00001004276	Illumina HiSeq 4000,NextSeq 500	400

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