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Neuroblastoma and adrenal gland single-cell study

Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. However, the cellular origin of neuroblastoma remains to be defined. Here, we study single-cell transcriptomes of neuroblastomas and normal human developing adrenal glands at various stages of embryonic and fetal development. We define normal differentiation trajectories during adrenal medullary development and identify the cellular origin of neuroblastoma. Importantly, adrenergic and mesenchymal neuroblastomas with varying clinical phenotypes match different temporal states along normal differentiation trajectories, with the degree of differentiation corresponding to clinical prognosis.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006624 Illumina HiSeq 4000 Illumina NovaSeq 6000 31
Publications Citations
Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model.
Nat Commun 13: 2022 2549
Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes.
Nat Cancer 3: 2022 1228-1246