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Single-cell analysis for metastatic gastric adenocarcinoma

Intra-tumoral heterogeneity (ITH) is the fundamental property of cancer, however, the origins of ITH remain poorly understood. Here we performed single-cell RNA sequencing of peritoneal carcinomatosis (PC) from patients with advanced gastric adenocarcinoma (GAC), constructed a transcriptome map of 45,048 PC cells, profiled the transcriptome states of diverse tumor cell lineages and types, incisively explored ITH of PC tumor cells, and identified significant correlates with patient survival.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006172 Illumina NovaSeq 6000 15
Publications Citations
Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma.
Nat Med 27: 2021 141-151
Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects.
Front Oncol 13: 2023 1074268