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Defective mitophagy and enhanced oxidative stress dictate regulatory T cell impairment in autoimmunity

Regulatory T cell (Treg) impairment is a common denominator of autoimmune pathologies. Despite the extensive characterization of Treg cell phenotype in autoimmunity, the molecular mechanisms underlying their deterioration remain ill defined. To investigate Treg dysfunction during autoimmunity we performed transcriptomic analysis of CD4+CD25highCD127- Treg cells from peripheral blood of patients with autoimmunity.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005446 NextSeq 500 27
EGAD00001006193 42
Publications Citations
Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity.
Cell Metab 32: 2020 591-604.e7
Dissecting the role of <i>CSF2RB</i> expression in human regulatory T cells.
Front Immunol 13: 2022 1005965