Defective mitophagy and enhanced oxidative stress dictate regulatory T cell impairment in autoimmunity
Regulatory T cell (Treg) impairment is a common denominator of autoimmune pathologies. Despite the extensive characterization of Treg cell phenotype in autoimmunity, the molecular mechanisms underlying their deterioration remain ill defined. To investigate Treg dysfunction during autoimmunity we performed transcriptomic analysis of CD4+CD25highCD127- Treg cells from peripheral blood of patients with autoimmunity.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
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Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity.
Cell Metab 32: 2020 591-604.e7
Dissecting the role of <i>CSF2RB</i> expression in human regulatory T cells.
Front Immunol 13: 2022 1005965