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Identifying the role of ID3 in DNA repair and maintenance of genome integrity

The inhibitor of DNA-binding 3 (ID3) is a transcriptional repressor protein that limits the binding of basic helix­loop-helix (bHLH) transcription factors to DNA. Preliminary results from our lab confirm that cellular depletion of ID3 is associated with an impaired DNA damage response. we hypothesize that ID3 has the potential to epigenetically affect DNA repair. This is based on our observation that upon cellular ID3 knockdown, a reduction of chromatin-bound H4K16ac and H3K36me3.

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Dataset ID Description Technology Samples
EGAD00001008198 Illumina NovaSeq 6000 1
EGAD00001008199 Illumina NovaSeq 6000 1
Publications Citations
ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition.
Nucleic Acids Res 49: 2021 11666-11689