Identifying the role of ID3 in DNA repair and maintenance of genome integrity
The inhibitor of DNA-binding 3 (ID3) is a transcriptional repressor protein that limits the binding of basic helixloop-helix (bHLH) transcription factors to DNA. Preliminary results from our lab confirm that cellular depletion of ID3 is associated with an impaired DNA damage response. we hypothesize that ID3 has the potential to epigenetically affect DNA repair. This is based on our observation that upon cellular ID3 knockdown, a reduction of chromatin-bound H4K16ac and H3K36me3.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001008198||Illumina NovaSeq 6000||1|
|EGAD00001008199||Illumina NovaSeq 6000||1|
ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition.
Nucleic Acids Res 49: 2021 11666-11689