WES sequencing of malignant peripheral nerve sheath tumours

Investigate the genomic landscape of MPNST tumours. Cases where a diagnosis of MPNST had been considered in the differential diagnosis with a variable degree of confidence was included. The diagnosis of MPNST was excluded in 12/51 (49 cases had WES data) of the sequenced tumours following review of the pathology, new IHC, molecular tests and clinical information. Article: Lyskjær et al, 2020, J Pathol, "H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours".

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001006253	WES from 51 cases initially diagnosed as Malignant Nerve Sheath Tumours (MPNST) and RNA sequencing data from 10 MPNST cases. Find more information in article: Lyskjær et al, 2020, J Pathol, "H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours".	Illumina HiSeq 2500	98

Publications	Citations
H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours. Lyskjaer I, Lindsay D, Tirabosco R, Steele CD, Lombard P, Strobl AC, Rocha AM, Davies C, Ye H, Bekers E, Ingruber J, Lechner M, Amary F, Pillay N, Flanagan AM. J Pathol 252: 2020 151-164	9