Somatic mutations in healthy and leukemic blood progenitors reveal evolutionary mechanisms underlying childhood leukemia and differential patient outcome

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001006338	Whole genome sequencing data (Illumina HiSeq and NovaSeq) of clonal cultures derived from pediatric human bone marrow-derived hematopoietic stem and multipotent progenitor cells (in total 44 samples from 10 donors) and bulk pediatric acute myeloid leukemia blasts (in total 6 samples from 6 patients) to study the mutation accumulation.	HiSeq X Ten Illumina NovaSeq 6000	118

Publications	Citations
Mutation signatures of pediatric acute myeloid leukemia and normal blood progenitors associated with differential patient outcomes. Brandsma AM, Bertrums EJM, van Roosmalen MJ, Hofman DA, Oka R, Verheul M, Manders F, Ubels J, Belderbos ME, van Boxtel R. Blood Cancer Discov 2: 2021 484-499	8
Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells. Manders F, van Dinter J, van Boxtel R. iScience 25: 2022 105610	1