Study

Genomewide detection of cytosine methylation by single molecule real-time sequencing

Study ID Alternative Stable ID Type
EGAS00001004642 Other

Study Description

5-methylcytosine (5mC) is an important type of epigenetic modification. In this study, we enhanced 5mC detection using SMRT sequencing by holistically analyzing kinetic signals of a DNA polymerase and sequence context for every base within a measurement window. We employed a convolutional neural network to train a methylation classification model. This methodology has provided a system for simultaneous genome-wide genetic and epigenetic analyses. 

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001006875
In this study, we enhanced 5mC detection using SMRT sequencing by holistically analyzing kinetic signals of a DNA polymerase and sequence context for every base within a measurement window. We employed a convolutional neural network to train a methylation classification model.
NextSeq 500,Sequel II 42

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