Study
Genomewide detection of cytosine methylation by single molecule real-time sequencing
Study ID | Alternative Stable ID | Type |
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EGAS00001004642 | Other |
Study Description
5-methylcytosine (5mC) is an important type of epigenetic modification. In this study, we enhanced 5mC detection using SMRT sequencing by holistically analyzing kinetic signals of a DNA polymerase and sequence context for every base within a measurement window. We employed a convolutional neural network to train a methylation classification model. This methodology has provided a system for simultaneous genome-wide genetic and epigenetic analyses.
Study Datasets 1 dataset.
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Dataset ID | Description | Technology | Samples |
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EGAD00001006875 |
In this study, we enhanced 5mC detection using SMRT sequencing by holistically analyzing kinetic signals of a DNA polymerase and sequence context for every base within a measurement window. We employed a convolutional neural network to train a methylation classification model.
|
NextSeq 500,Sequel II | 42 |
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