International consensus definition of DNA methylation subgroups in juvenile myelomonocytic leukemia

Known clinical and genetic markers have limitations in predicting disease course and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation (DNAme) patterns in JMML have correlated with outcome across multiple studies, suggesting it as a biomarker to improve patient stratification. However, standardized approaches to classify JMML based on DNAme patterns are lacking. We therefore sought to define an international consensus for DNAme subgroups in JMML and develop classification methods for clinical implementation.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

3 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00010001998	DNA methylation analysis of JMML patients from Europe, Japan and USA using EPIC arrays	Infinium HumanMethylation450K and EPIC BeadChip	32
EGAD00010001999	DNA methylation analysis of JMML patients from Europe, Japan and USA using 450k arrays	Infinium HumanMethylation450K and EPIC BeadChip	292
EGAD00010002000	DNA methylation analysis of JMML patients from Europe, Japan and USA using EPIC arrays	Infinium HumanMethylation450K and EPIC BeadChip	47

Publications	Citations
International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia. Schönung M, Meyer J, Nöllke P, Olshen AB, Hartmann M, Murakami N, Wakamatsu M, Okuno Y, Plass C, Loh ML, Niemeyer CM, Muramatsu H, Flotho C, Stieglitz E, Lipka DB. Clin Cancer Res 27: 2021 158-168	25