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UROMOL 2020 - RNA-seq data

The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we performed a large integrative multi-omics analysis of patients diagnosed with NMIBC (n=834). Transcriptomic analysis identifies four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subtyping and the level of chromosomal instability provide independent prognostic value beyond established prognostic clinicopathological parameters.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006656 Illumina HiSeq 2000 Illumina MiSeq Illumina NovaSeq 6000 NextSeq 550 535
Publications Citations
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
Nat Commun 12: 2021 2301
A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma.
Sci Rep 12: 2022 16538