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Integrative Analysis of Pediatric Acute Leukemia Identifies Acute Myeloid/T-Lymphoblastic Leukemia Subtype that Spans a T Lineage and Myeloid Continuum with Distinct Prognoses

Genomic characterization of pediatric patients with acute myeloid leukemia (AML) has revealed age specific mutational spectrums, distinguishing it biologically from adult patients. While gene expression profiling signatures can differentiate subsets of pediatric AML, its clinical utility in risk stratification has remained limited.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006442 Illumina HiSeq 2000 184
EGAD00001006443 Illumina HiSeq 2000 260
EGAD00001006444 Illumina HiSeq 2000 132
Publications Citations
Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.
Blood Cancer Discov 2: 2021 586-599
Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication.
Nat Commun 14: 2023 1739
A new genomic framework to categorize pediatric acute myeloid leukemia.
Nat Genet 56: 2024 281-293