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Single-cell RNA sequencing of bronchoalveolar lavages from COVID-19 patients

Discriminating mild-moderate from critical COVID-19 disease by innate and adaptive immune single-cell profiling of bronchoalveolar lavages.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006893 Illumina NovaSeq 6000 35
Publications Citations
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages.
Cell Res 31: 2021 272-290
153
Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution.
iScience 24: 2021 102738
5
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity.
Nat Commun 12: 2021 4117
111
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
JCI Insight 6: 2021 e150862
40
Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host.
Nat Commun 12: 2021 6243
23
Single-Cell Landscape of Lungs Reveals Key Role of Neutrophil-Mediated Immunopathology during Lethal SARS-CoV-2 Infection.
J Virol 96: 2022 e0003822
3
Metabolic modeling of single bronchoalveolar macrophages reveals regulators of hyperinflammation in COVID-19.
iScience 25: 2022 105319
3
Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates.
Front Immunol 13: 2022 861251
8
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2.
Cell Host Microbe 31: 2023 243-259.e6
9
A cross entropy test allows quantitative statistical comparison of t-SNE and UMAP representations.
Cell Rep Methods 3: 2023 100390
2
C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps.
J Clin Invest 133: 2023 e163105
0