Study
Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001004752 | Other |
Study Description
Inherited lung cancer risk, particularly in non-smokers, is poorly understood. Genomic and ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden (TMB), and specific driver mutations in EGFR, KRAS, and STK11. A local Native American ancestry risk score predicted EGFR and KRAS mutation frequency more strongly than global ancestry, suggesting that germline genetics (rather than environmental exposure) underlie these disparities.
Study Datasets 2 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001006552 |
Raw data from cancer panel sequencing of lung adenocarcinomas from admixed Latin American populations. Predominantly samples carrying known oncogene mutations (n=581).
|
578 | |
| EGAD00001006571 |
Raw data from cancer panel sequencing of lung adenocarcinomas from admixed Latin American populations, predominantly samples without known oncogene mutations (n=532).
|
Illumina HiSeq 2500 | 532 |
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