Study

Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations

Study ID Alternative Stable ID Type
EGAS00001004752 Other

Study Description

Inherited lung cancer risk, particularly in non-smokers, is poorly understood. Genomic and ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden (TMB), and specific driver mutations in EGFR, KRAS, and STK11. A local Native American ancestry risk score predicted EGFR and KRAS mutation frequency more strongly than global ancestry, suggesting that germline genetics (rather than environmental exposure) underlie these disparities.

Study Datasets 2 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006552
Raw data from cancer panel sequencing of lung adenocarcinomas from admixed Latin American populations. Predominantly samples carrying known oncogene mutations (n=581).
578
EGAD00001006571
Raw data from cancer panel sequencing of lung adenocarcinomas from admixed Latin American populations, predominantly samples without known oncogene mutations (n=532).
Illumina HiSeq 2500 532

Who archives the data?

There are no publications available