Study

Colorectal cancer cells possess an equipotent capacity to enter a developmental pausing-like state to survive chemotherapy

Study ID Alternative Stable ID Type
EGAS00001004773 Cancer Genomics

Study Description

Study Datasets 2 datasets.

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Dataset ID Description Technology Samples
EGAD00001006847
NA
Illumina HiSeq 2500 12
EGAD00001006849
Cancer cells enter a reversible drug tolerant persister (DTP) state to evade death from both chemotherapies and targeted agents. It is increasingly appreciated that the DTP state is an important driver of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer xenograft models to identify and characterize the cancer cells capable of generating DTPs in response to standard-of-care chemotherapy. Barcode analysis revealed no ... (Show More)
Illumina HiSeq 2500 12

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