Methylation analysis for plasma DNA of patients with organ transplantation

Study

Study ID	Alternative Stable ID	Type
EGAS00001004788		Other

Study Description

We developed Genetic-Epigenetic Tissue Mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated this approach by showing that, in pregnant women, circulating DNA carrying fetal-specific alleles was entirely placenta-derived.

Study Datasets 1 dataset.

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Dataset ID	Description	Technology	Samples
EGAD00001007041	We developed Genetic-Epigenetic Tissue Mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We developed Genetic-Epigenetic Tissue Mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues.	Illumina HiSeq 4000,NextSeq 500	152

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