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Methylation analysis for plasma DNA of patients with organ transplantation

We developed Genetic-Epigenetic Tissue Mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated this approach by showing that, in pregnant women, circulating DNA carrying fetal-specific alleles was entirely placenta-derived.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001007041 Illumina HiSeq 4000 NextSeq 500 152
Publications Citations
Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology.
Elife 10: 2021 e64356