Immune trajectory of response and adverse effect in immunotherapy-treated hepatocellular carcinoma

Study ID Alternative Stable ID Type
EGAS00001004843 Other

Study Description

Whilst anti-PD1 immune checkpoint blockade (ICB) has revolutionised treatment for many cancers, its response rates in hepatocellular carcinoma (HCC) remain modest, coupled with common incidences of immune-related adverse events (irAEs). To identify biomarkers and decipher the mechanisms for response and irAEs, we performed multi-dimensional immunoprofiling on peripheral blood and tissue collected before and during anti-PD1 ICB treatment from HCC patients. Single-cell analyses enabled us to identify peripheral biomarkers, in particular, CD11c+ antigen-presenting cells with varying degrees of HLA-DR expression and CD8 effector memory (EM) T cells with CXCR3 tissue-homing capability that are associated with both response and irAEs. We also dissected the mechanisms behind how these immune subsets interface between response and toxicity, showing their intersecting yet diverging trajectories leading to these distinct clinical fates. This study offers new insights on the mechanisms and potentially novel strategies to enhance response and ameliorate irAEs in cancer immunotherapy.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
10 samples (one baseline, 9 on-treatment). Fastq files containing 5'GEx data, prepared using 10x Genomics pipeline, sequenced on Illumina HiSeq4000.
Illumina HiSeq 4000 10

Who archives the data?

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