Somatic_evolution_in_the_psoriatic_skin

We will use laser capture microdissection to dissect groups of a few hundred cells, from which we will isolate and sequence nucleic acids. We aim to whole-genome, whole-exome and RNA sequence the samples in effort to understand the accumulation of somatic mutations in psoriasis and their effect on transcription.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001011265	Data from sequencing of microbiopsies of keratinocytes isolated via laser capture microscopy from lesional and non-lesonal skin biopsies from psoriasis patients.	Illumina NovaSeq 6000	1211

Publications	Citations
Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin. Olafsson S, Rodriguez E, Lawson ARJ, Abascal F, Huber AR, Suembuel M, Jones PH, Gerdes S, Martincorena I, Weidinger S, Campbell PJ, Anderson CA. Nat Genet 55: 2023 1892-1900	6