Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
Studies over the past decade characterized murine regulatory T cells (Tregs) with the capacity to promote tissue regeneration. In humans, such a population of tissue-repair Treg cells has not been discovered yet. Using single-cell chromatin accessibility profiles of murine and human tissue Treg cells, we defined a species-conserved and microbiota-independent repair Treg signature, with a prevailing footprint of the transcription factor BATF. Combining this signature with gene expression profiling and TCR fate mapping, we identified a population of tissue-like Treg cells in peripheral blood, characterized by the expression of BATF, CCR8 and HLA-DR. Human BATF+CCR8+ Treg cells from normal skin and adipose tissue shared features with tumor-resident Treg and tissue T-follicular helper (Tfh) cells. Inducing a Tfh-like differentiation program in naive Treg cells partially recapitulated human tissue Treg characteristics, including enhanced wound healing potential
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001006779 | NextSeq 500 | 15 | |
EGAD00001007660 | NextSeq 550 | 8 | |
EGAD00001007661 | NextSeq 550 | 17 | |
EGAD00001007662 | NextSeq 550 | 8 | |
EGAD00001007663 | NextSeq 550 | 50 | |
EGAD00001007664 | NextSeq 550 | 43 | |
EGAD00001007665 | NextSeq 550 | 17 |
Publications | Citations |
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Obesity-induced dysregulation of skin-resident PPARγ<sup>+</sup> Treg cells promotes IL-17A-mediated psoriatic inflammation.
Immunity 56: 2023 1844-1861.e6 |
12 |
Analyzing sex imbalance in EGA and dbGaP biological databases: Recommendations for better practices.
iScience 27: 2024 110831 |
0 |