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Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

Studies over the past decade characterized murine regulatory T cells (Tregs) with the capacity to promote tissue regeneration. In humans, such a population of tissue-repair Treg cells has not been discovered yet. Using single-cell chromatin accessibility profiles of murine and human tissue Treg cells, we defined a species-conserved and microbiota-independent repair Treg signature, with a prevailing footprint of the transcription factor BATF. Combining this signature with gene expression profiling and TCR fate mapping, we identified a population of tissue-like Treg cells in peripheral blood, characterized by the expression of BATF, CCR8 and HLA-DR. Human BATF+CCR8+ Treg cells from normal skin and adipose tissue shared features with tumor-resident Treg and tissue T-follicular helper (Tfh) cells. Inducing a Tfh-like differentiation program in naive Treg cells partially recapitulated human tissue Treg characteristics, including enhanced wound healing potential

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006779 NextSeq 500 15
EGAD00001007660 NextSeq 550 8
EGAD00001007661 NextSeq 550 17
EGAD00001007662 NextSeq 550 8
EGAD00001007663 NextSeq 550 50
EGAD00001007664 NextSeq 550 43
EGAD00001007665 NextSeq 550 17
Publications Citations
Obesity-induced dysregulation of skin-resident PPARγ<sup>+</sup> Treg cells promotes IL-17A-mediated psoriatic inflammation.
Immunity 56: 2023 1844-1861.e6
12
Analyzing sex imbalance in EGA and dbGaP biological databases: Recommendations for better practices.
iScience 27: 2024 110831
0