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Multi-institutional collaboration to characterize 5hmC in prostate cancer, both tumor biopsies and cfDNA.

This study used pull-down sequencing to measure 5-hydroxymethylcytosine (5hmC) levels in tissue biopsy specimens from patients with localized and metastatic castration-resistant (mCRPC) prostate cancer. For a subset of the cohort, the same technique was used to sequence cell-free DNA (cfDNA) isolated from patient plasma. To assess 5hmC levels in cfDNA from a larger number of specimens, plasma samples from another mCRPC cohort were also assayed with this method. The larger cohort of cfDNA samples was further anlayzed with a targeted sequencing gene panel.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001008462 Illumina HiSeq 2500 NextSeq 550 596
Publications Citations
The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.
Cancer Res 82: 2022 3888-3902