The genomic landscape of childhood acute lymphoblastic leukaemia with intrachromosomal amplification of chromosome 21 (iAMP21-ALL)

Study ID Alternative Stable ID Type
EGAS00001004998 Other

Study Description

Intrachromosomal amplification of chromosome 21 (iAMP21) results from breakage-fusion-bridge cycles and chromothripsis defines a cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukemia (B-ALL) cases associated with a poor prognosis. To systematically characterize the mechanism of somatic alternations in iAMP21, we perform integrated genomic, cytogenetic and transcriptomic analysis of 128 cases.

Study Datasets 2 datasets.

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Dataset ID Description Technology Samples
iAMP21 WGS, total of 224 samples
HiSeq X Ten,Illumina HiSeq 2500,Illumina NovaSeq 6000 224
RNAseq samples from the iAMP21 study
Illumina HiSeq 2500,Illumina HiSeq 4000,NextSeq 550 88

Who archives the data?