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Transcriptomic and epigentic analysis of human peripheral blood NK cell subsets revealing role of Bcl11b in differentiation

Transcriptomic analysis of seven human peripheral blood NK cell subsets and three T cell subsets purified from healthy cytomeglovirus seropositive donors. Epigenetic analysis including identification of open chromatin and active enhancer elements confirms key regulatory factors defining an NK cell differentiation axis. Chromatin-immunoprecipitation sequencing reveals contribution of key transcription factors associated with NK cell differentiation including Bcl11b.

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Dataset ID Description Technology Samples
EGAD00001008449 Illumina HiSeq 2500 Illumina HiSeq 3000 1
Publications Citations
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation.
Sci Immunol 6: 2021 eabc9801
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