Combining dasatinib and IFN-α in CML – immunomodulatory effects linked to treatment response and adverse events

Study

Study ID	Alternative Stable ID	Type
EGAS00001005049		Other

Study Description

We pooled 100,000 cells from the 12 scRNA+TCRab-seq samples from peripheral blood from three time points (n=4, samples at 0, 3, and 12 months) to understand the landscape of immune subsets in CML during the course of dasatinib+IFN-α treatment

Study Datasets 2 datasets.

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Dataset ID	Description	Technology	Samples
EGAD00001009085	TCRab sequencing of viably frozen cells from 12 samples from four chronic-phase chronic myeloid leukemia patients. The raw data is available as fastq files. TCRab sequencing of viably frozen cells from 12 samples from four chronic-phase chronic myeloid leukemia patients. The raw data is available as fastq files.	Illumina HiSeq 2500	48
EGAD00001009086	Single-cell RNA sequencing of viably frozen cells from 12 samples from four chronic-phase chronic myeloid leukemia patients. The raw data is available as fastq files. Single-cell RNA sequencing of viably frozen cells from 12 samples from four chronic-phase chronic myeloid leukemia patients. The raw data is available as fastq files.	Illumina NovaSeq 6000	48

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