Bone marrow derived stromal cells from Myelodysplastic Syndromes

In this study we performed exome sequencing of bone marrow derived, in-vitro expanded mesenchymal stromal cells from patients with Myelodysplastic Syndromes in order to assess clonal mutations in the non hematopoietic compartment. We used bone marrow mononuclear cells as germline controls. Validation was carried out with amplicon based resequencing. Alongside we provide RNA Sequencing of MDS and healthy MSCs.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001006968	bam files, mapped to hg19 after dedup, recal, recalibration and clipping of overlapping redas	Illumina HiSeq 4000 Illumina MiSeq Illumina NovaSeq 6000	210
EGAD00001007760	This dataset contains bam files mapped to hg19 that either were primary bone marrow cells or sorted human cells after long term engraftment in NSG mice.	Illumina NovaSeq 6000	229

Publications	Citations
Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo. Jann JC, Mossner M, Riabov V, Altrock E, Schmitt N, Flach J, Xu Q, Nowak V, Obländer J, Palme I, Weimer N, Streuer A, Jawhar A, Darwich A, Jawhar M, Metzgeroth G, Nolte F, Hofmann WK, Nowak D. Nat Commun 12: 2021 6170	13