The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001008144	SNP data for 313 loci required for calculation of the Breast cancer PRS		-
EGAD00001008145	SNP data of 28 sites required for the Ovarian cancer PRS (controls)		-
EGAD00010002079	Raw methylation data from cervical samples in controls.	Illumina MethylationEPIC Array	1094
EGAD00010002080	Raw methylation data from cervical samples in controls.	Illumina MethylationEPIC Array	202
EGAD00010002081	Raw methylation data from cervical samples in individuals with breast cancer.	Illumina MethylationEPIC Array	442
EGAD00010002082	Raw methylation data from buccal samples in individuals with breast cancer.	Illumina MethylationEPIC Array	200
EGAD00010002470	Raw methylation data from blood samples in breast cancer cases.	Illumina MethylationEPIC Array	105
EGAD00010002471	Raw methylation data from blood samples in controls.	Illumina MethylationEPIC Array	211

Publications	Citations
The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples. Barrett JE, Herzog C, Jones A, Leavy OC, Evans I, Knapp S, Reisel D, Nazarenko T, Kim YN, Franchi D, Ryan A, Franks J, Bjørge L, Zikan M, Cibula D, Harbeck N, Colombo N, Dudbridge F, Jones L, Sundström K, Dillner J, Rådestad AF, Gemzell-Danielsson K, Pashayan N, Widschwendter M. Nat Commun 13: 2022 449	21
The DNA methylome of cervical cells can predict the presence of ovarian cancer. Barrett JE, Jones A, Evans I, Reisel D, Herzog C, Chindera K, Kristiansen M, Leavy OC, Manchanda R, Bjørge L, Zikan M, Cibula D, Widschwendter M. Nat Commun 13: 2022 448	29
Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock. Barrett JE, Herzog C, Kim YN, Bartlett TE, Jones A, Evans I, Cibula D, Zikan M, Bjørge L, Harbeck N, Colombo N, Howell SJ, Rådestad AF, Gemzell-Danielsson K, Widschwendter M. Genome Biol 23: 2022 52	7
A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets. Herzog C, Marín F, Jones A, Evans I, Reisel D, Redl E, Schreiberhuber L, Paytubi S, Pelegrina B, Carmona Á, Peremiquel-Trillas P, Frias-Gomez J, Pineda M, Brunet J, Ponce J, Matias-Guiu X, de Sanjosé S, Alemany L, Olaitan A, Wong M, Jurkovic D, Crosbie EJ, Rosenthal AN, Bjørge L, Zikan M, Dostalek L, Cibula D, Sundström K, Dillner J, Costas L, Widschwendter M. J Clin Oncol 40: 2022 3828-3838	28
DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment. Herzog C, Jones A, Evans I, Zikan M, Cibula D, Harbeck N, Colombo N, Rådestad AF, Gemzell-Danielsson K, Pashayan N, Widschwendter M. NPJ Precis Oncol 7: 2023 99	2
Cigarette Smoking and E-cigarette Use Induce Shared DNA Methylation Changes Linked to Carcinogenesis. Herzog C, Jones A, Evans I, Raut JR, Zikan M, Cibula D, Wong A, Brenner H, Richmond RC, Widschwendter M. Cancer Res 84: 2024 1898-1914	13
Validation of blood-based detection of breast cancer highlights importance for cross-population validation. Theeuwes B, Ambatipudi S, Herceg Z, Herzog CM, Widschwendter M. Nat Commun 16: 2025 2164	1