WES of clonally related neuroblastoma and teratoma
Mature teratomas are usually benign tumors that rarely undergo malignant transformation. We report an advanced neuroblastoma arising in a mature teratoma of the ovary. Whole-exome sequencing identified extensive copy-neutral LOH in both neuroblastoma and teratoma elements, suggesting that the neuroblastoma evolved from the teratoma.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
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|EGAD00001007039||Illumina HiSeq 2500||3|
Clonal evidence for the development of neuroblastoma with extensive copy-neutral loss of heterozygosity arising in a mature teratoma.
Cancer Sci 112: 2021 2921-2927