Study

Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia

Study ID Alternative Stable ID Type
EGAS00001005180 Other

Study Description

We evaluated the efficacy of proteolysis-targeting chimeras (PROTACs) directed against Janus kinases. Solving the structure of FDA-approved type I JAK inhibitors ruxolitinib and baricitinib bound to the JAK2 JH1 tyrosine kinase domain enabled the rational design and optimization of Cereblon (CRBN)-directed JAK PROTACs utilizing multiple derivatives of JAK inhibitors, linkers and CRBN-specific molecular glues. The resulting JAK PROTACs were evaluated for target degradation by proteomic approaches, and activity tested in CRLF2-rearranged cell line and xenograft models of ALL.

Study Datasets 2 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001007569
RNAseq data set, Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia
Illumina NovaSeq 6000 11
EGAD00001007570
WGS data set of 11 xenograft samples, Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia
Illumina NovaSeq 6000 11

Who archives the data?

There are no publications available