Study

Whole genome sequence and RNA-seq data from paired tumour and germline samples from mesothelioma patients.

Study ID Alternative Stable ID Type
EGAS00001005196 Other

Study Description

Malignant pleural mesothelioma (MPM) has a poor overall survival with few treatment options. Whole genome sequencing (WGS) combined with RNA sequencing (RNA-seq) analysis of the immune features of MPM offers the prospect of identifying changes that could inform future clinical trials. We analysed somatic mutation and RNA-seq data from 229 MPM samples, including 58 MPM samples that had undergone WGS from our own institutions, together with other published data. This combined analysis identified somatic driver genes, including newly identified candidate genes. Whole genome doubling was a frequent event that correlated with shorter survival. Mutational signature analysis revealed dominant signatures and showed that defects in homologous recombination repair were infrequent in our cohort. Within the tumour immune environment we identified high M2 macrophage infiltrate linked with MMP2, MMP14, TGFB1 and CCL2 expression, representing an immunosuppressive environment. A small subset of samples had a higher proportion of CD8 T cells and a high cytolytic score, suggesting a ‘hot’ immune ... (Show More)

Study Datasets 3 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001007874
RNA-seq data from paired tumour and germline samples from mesothelioma patients for study EGAS00001005196
Illumina HiSeq 2500,Illumina NovaSeq 6000 42
EGAD00001008341
Whole genome sequencing from paired tumour and germline malignant pleural mesothelioma samples
HiSeq X Ten 74
EGAD00001008447
Whole genome sequence from paired tumour and germline samples from mesothelioma patients
HiSeq X Ten 42

Who archives the data?

There are no publications available