The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

Study ID Alternative Stable ID Type
EGAS00001005201 Other

Study Description

Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes (TIL/Tc) could determine disease course at different stages in cancer progression. We show that the diversity of the TIL/Tc TCR at baseline is prognostic in various cancers, whereas in metastatic melanoma TIL/Tc TCR clonality at baseline is predictive for activity and efficacy of PD1 blockade immunotherapy.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Transcriptomic sequencing on pre-immunotherapy melanoma patients.
Illumina HiSeq 2500 16

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