The distinct DNA methylome of acute lymphoblastic leukemia

Study ID Alternative Stable ID Type
EGAS00001005203 Other

Study Description

Here, using whole genome bisulfite sequencing (WGBS) data of over one hundred patients from multiple subtypes of acute lymphoblastic leukemia (ALL), controls samples and ALL cell lines, we show that in contrast to the prevailing paradigm, ALL samples exhibit CpG island hypermethylation but little to no global loss of methylation. The subtype-specific CpG island hypermethylation levels in T cell ALL span a broad range of methylation levels rather than previous binary classifications and are influenced by multiple factors, including TET2 expression.

Study Datasets 3 datasets.

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Dataset ID Description Technology Samples
WGS data set used in the study, 2 samples
Illumina HiSeq 2500 2
RNAseq data set used in the study, 10 samples
Illumina HiSeq 2500 10
WGBS data set used in the study, 96 samples
Illumina HiSeq 2000,Illumina NovaSeq 6000 96

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