Evolutionary trajectories and clonal migration underlying tumor progression and lymph node metastasis in resectable lung cancer

Study ID Alternative Stable ID Type
EGAS00001005242 Cancer Genomics

Study Description

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
In this prospective study, targeted deep sequencing was performed on a total of 160 primary tumors (474 regions) and 112 lymph nodes from 125 patients with stage I-III lung cancer (LuCaTH). Progressive evolution at clonal divergence scale was observed while specific driver events were positively selected for clonal sweeps during tumor development. Between-region genetic divergence (BRGD) of tumors were assessed and positively correlated with tumor differentiation. A machine learning algorithm ... (Show More)

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