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Single-cell RNA sequencing of 6 follicular lymphoma tumors

Follicular lymphoma (FL) is an indolent cancer of mature B-cells but carries increased risk of transformation to a more aggressive histology over time. We present here comprehensive profiling both tumor and immune compartments in 6 diagnostic FL biopsies by single-cell RNA sequencing. This confirmed results from 155 FL tumors characterized by mass cytometry (CyTOF) which revealed two distinct evolutionary trajectories with disparate risk of transformation and alternate biologies.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001007691 6
Publications Citations
Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk.
Nat Commun 13: 2022 6772