Single-cell RNA sequencing of 6 follicular lymphoma tumors
Follicular lymphoma (FL) is an indolent cancer of mature B-cells but carries increased risk of transformation to a more aggressive histology over time. We present here comprehensive profiling both tumor and immune compartments in 6 diagnostic FL biopsies by single-cell RNA sequencing. This confirmed results from 155 FL tumors characterized by mass cytometry (CyTOF) which revealed two distinct evolutionary trajectories with disparate risk of transformation and alternate biologies.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
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Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk.
Nat Commun 13: 2022 6772