Circulating tumor cell copy-number heterogeneity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

Study ID Alternative Stable ID Type
EGAS00001005301 Other

Study Description

Gatekeeper mutations are identified in only 50% of the cases at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors (TKIs). Circulating tumor cells (CTCs) are relevant tools to identify additional resistance mechanisms and can be sequenced at the single-cell level. Here, we provide in-depth investigation of copy number alteration (CNA) heterogeneity in phenotypically characterized CTCs at resistance to ALK-TKIs in ALK-positive non-small cell lung cancer.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Lowpass whole genome sequencing of 43 single CTCs and one tumor biopsy
Illumina HiSeq 2500 44

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