Need Help?

Correction of FFPE artefacts in WGS data

The ability to precisely characterise mutational signatures from FFPE-derived DNA has tremendous translational potential. However, sequencing of DNA derived from FFPE material is known to be riddled with artefacts. To correct for this, we introduce FFPEsig, a computational algorithm to rectify the formalin-induced artefacts in the mutational profile.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001007716 Illumina NovaSeq 6000 3
EGAD00001007723 Illumina NovaSeq 6000 3
Publications Citations
The mutational signatures of formalin fixation on the human genome.
Nat Commun 13: 2022 4487