Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure

This study present a molecular analysis of upper urinary tract urothelial tumours (UTUC) and urines of patients with past exposure to carcinogenic aristolochic acid (AA). Tumor exome and transcriptome sequencing revealed the AA-specific mutations in UTUC and identified deleterious mutations at both the gene and transcript levels.

Type: Other
Archiver: EGA European Genome-Phenome Archive

2 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001008137	This dataset includes mutation profiling by Whole-exome sequencing of 3 upper urinary tract urothelial tumours (UTUC).	Illumina HiSeq 2000	6
EGAD00001008138	This dataset includes transcription profiling by RNA-seq of 3 upper urinary tract urothelial tumours (UTUC).	Illumina HiSeq 2000	3

Publications	Citations
Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure. Karanović S, Ardin M, Tang Z, Tomić K, Villar S, Renard C, Venturini E, Lorch AH, Lee DS, Stipančić Ž, Slade N, Vuković Brinar I, Dittrich D, Karlović K, Borovečki F, Dickman KG, Olivier M, Grollman AP, Jelaković B, Zavadil J. Int J Cancer 150: 2022 374-386	2