Mongolia Western HCC

Study ID Alternative Stable ID Type
EGAS00001005364 Other

Study Description

Mongolia has the world’s highest incidence of hepatocellular carcinoma (HCC), with ~100 cases/105 inhabitants. We molecularly characterize the Mongolian (n=192) compared to Western HCCs (n=187) by RNA-seq and WES. Mongolian patients were predominantly younger, female, with HBV-HDV non-cirrhotic livers. Mongolian HCCs had higher rates of protein-coding mutations (121 vs 70 mut /tumor in West), and mutations in known (i.e. APOB) and putative HCC drivers (TSC2). A novel mutational signature (SBS Mongolia) was identified in 25% of cases associated with the carcinogenic DMS genotoxic signature. Two unique molecular classes enriched in HBV-HDV infection, female gender and inflamed tumors are described.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Total collection of Samples. Exome sequencing and RNAseq from Mongolia and Western HCC samples.
Illumina HiSeq 2500,Illumina NovaSeq 6000 550

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