Germline RUNX1 Variation and Predisposition to Childhood Acute Lymphoblastic
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Somatic mutations of RUNX1, which encodes the myeloid and lymphoid transcriptional factor RUNX1, are common in both B- and T- acute lymphoid leukemia (ALL) and are associated with poor prognosis of T-ALL. However, there has been no comprehensive investigation of the pattern or prevalence of RUNX1 germline mutation in both B- and T-ALL. Here we report germline RUNX1 variants in 1.23% of B-ALL and 2.11% of T-ALL, identifying 31 unique variants in 62 B-ALL and 18 unique variants in 26 T-ALL ... (Show More)
|Illumina NovaSeq 6000||16|