Induction of trained immunity by influenza vaccine: impact on COVID-19

1 Dataset 2 Publications

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Dataset ID	Description	Technology	Samples
EGAD00001007827	Cryopreserved PBMCs from 10 individuals before and after vaccination were used to perform single cell RNA sequencing. Equal number of cells per individual were pooled together (5 individuals per pool) and single-cell RNA sequencing was performed in paired-end mode on NovaSeq 6000 (Illumina) with a depth of 50,000 reads per cell. DNA was isolated from PBMCs and then used for genotyping by Illumina GSA Beadchip. This dataset contains the fastq sequence files, genotypes of the donors used for demultiplexing the pools and files indicating the linkages between individuals, pools and fastq files. The number of samples listed by EGA does not match the actual number of samples due to limitations on the upload scheme used.	Illumina NovaSeq 6000	4

Publications	Citations
Induction of trained immunity by influenza vaccination - impact on COVID-19. Debisarun PA, Gössling KL, Bulut O, Kilic G, Zoodsma M, Liu Z, Oldenburg M, Rüchel N, Zhang B, Xu CJ, Struycken P, Koeken VACM, Domínguez-Andrés J, Moorlag SJCFM, Taks E, Ostermann PN, Müller L, Schaal H, Adams O, Borkhardt A, Ten Oever J, van Crevel R, Li Y, Netea MG. PLoS Pathog 17: 2021 e1009928	73
Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population. Kumar S, Zoodsma M, Nguyen N, Pedroso R, Trittel S, Riese P, Botey-Bataller J, Zhou L, Alaswad A, Arshad H, Netea MG, Xu CJ, Pessler F, Guzmán CA, Graca L, Li Y. Sci Adv 10: 2024 eadq7006	0