Need Help?

Role of cohesin/CTCF in human monocyte differentiation

Here we study genome architecture in a postmitotic differentiation setting, the differentiation of human blood monocytes (MO). We profiled and compared epigenetic, transcriptome and 3D conformation landscapes during MO differentiation (either into dendritic cells or macrophages) across the genome, with and without siRNA-mediated depletion of RD21 or CTCF, and detected numerous architectural changes, ranging from higher level compartments

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001007952 NextSeq 550 24
EGAD00001007953 NextSeq 550 39
EGAD00001007954 NextSeq 550 120
EGAD00001007955 NextSeq 550 42
EGAD00001007956 NextSeq 550 63
Publications Citations
Postmitotic differentiation of human monocytes requires cohesin-structured chromatin.
Nat Commun 13: 2022 4301