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Long cell-free DNA molecules in maternal plasma

We revealed a large population of long cell-free DNA molecules (up to 23,635 bp in length) in maternal plasma and developed an approach which leveraged the abundance of CpG sites on long molecules to deduce the tissue of origin of individual plasma DNA molecules based on single-molecule methylation analysis. We illustrated how such an approach may be utilized to achieve noninvasive prenatal testing of monogenic diseases. We also revealed a reduction in amounts of such long cell-free DNA molecules and a different end motif profile in maternal plasma DNA from pregnancies with preeclampsia.

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Dataset ID Description Technology Samples
EGAD00001008721 Sequel 20
EGAD00001008732 Sequel 14
EGAD00001008747 Sequel 1
EGAD00001008748 Sequel 18
Publications Citations
Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma.
Proc Natl Acad Sci U S A 118: 2021 e2114937118